Charles C Wykoff Selected Research

aflibercept

1/2022	Final Outcomes from the Randomized RECOVERY Trial of Aflibercept for Retinal Nonperfusion in Proliferative Diabetic Retinopathy.
1/2022	Efficacy Outcomes of Brolucizumab Versus Aflibercept in Neovascular Age-Related Macular Degeneration Patients with Early Residual Fluid.
1/2022	MERLIN: Phase 3a, Multicenter, Randomized, Double-Masked Trial of Brolucizumab in Participants with Neovascular Age-Related Macular Degeneration and Persistent Retinal Fluid.
12/2021	Antivascular endothelial growth factor agents for wet age-related macular degeneration: an IRIS registry analysis.
11/2021	The 2-Year Leakage Index and Quantitative Microaneurysm Results of the RECOVERY Study: Quantitative Ultra-Widefield Findings in Proliferative Diabetic Retinopathy Treated with Intravitreal Aflibercept.
9/2021	Real-Time Diabetic Retinopathy Severity Score Level versus Ultra-Widefield Leakage Index-Guided Management of Diabetic Retinopathy: Two-Year Outcomes from the Randomized PRIME Trial.
9/2021	Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy: Results From the PANORAMA Randomized Clinical Trial.
6/2021	Brolucizumab vs aflibercept and ranibizumab for neovascular age-related macular degeneration: a cost-effectiveness analysis.
5/2021	Intravitreal Aflibercept Injection vs Sham as Prophylaxis Against Conversion to Exudative Age-Related Macular Degeneration in High-risk Eyes: A Randomized Clinical Trial.
1/2021	Effect of Aflibercept on Diabetic Retinopathy Severity and Visual Function in the RECOVERY Study for Proliferative Diabetic Retinopathy.

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Charles C Wykoff Research Topics

Disease

40	Macular Edema 09/2022 - 01/2013
35	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2022 - 07/2014
33	Macular Degeneration (Age-Related Maculopathy) 10/2022 - 03/2013
10	Retinal Vein Occlusion 09/2022 - 09/2014
6	Retinal Detachment (Retinal Detachments) 10/2022 - 01/2021
6	Inflammation (Inflammations) 10/2022 - 01/2018
6	Hypoxia (Hypoxemia) 01/2022 - 06/2002
5	Retinal Perforations 07/2022 - 01/2010
5	Endophthalmitis (Ophthalmia) 01/2020 - 04/2011
4	Choroidal Neovascularization 01/2022 - 01/2016
4	Geographic Atrophy 01/2022 - 01/2020
4	Edema (Dropsy) 01/2018 - 12/2014
3	Ischemia 01/2022 - 01/2013
3	Retinal Vasculitis 01/2022 - 01/2017
3	Diabetes Mellitus 01/2021 - 06/2018
3	Cataract (Cataracts) 08/2019 - 09/2010
3	Atrophy 01/2018 - 01/2013
2	Central Serous Chorioretinopathy 11/2022 - 01/2009
2	Microaneurysm 11/2021 - 01/2017
2	COVID-19 01/2021 - 10/2020
2	Vascular Diseases (Vascular Disease) 01/2021 - 01/2020
2	Retinal Diseases 08/2017 - 01/2011
2	Neoplasms (Cancer) 05/2013 - 06/2002
1	Polypoidal Choroidal Vasculopathy 11/2022
1	Blister (Bulla) 01/2022
1	Eye Diseases (Eye Disease) 01/2020
1	Uveitis 08/2019
1	Epilepsy (Aura) 02/2018
1	Choroidal Effusions 01/2018
1	Myocardial Infarction 01/2018
1	Stroke (Strokes) 01/2018
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 12/2017
1	Cysts 11/2017
1	Delayed Hypersensitivity (Hypersensitivity, Type IV) 01/2017
1	Neovascular Glaucoma 01/2017
1	Hemorrhage 01/2016
1	Wounds and Injuries (Trauma) 01/2016

Drug/Important Bio-Agent (IBA)

33	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2022 - 01/2011
30	Retinaldehyde (Retinal)IBA 01/2022 - 02/2013
27	afliberceptIBA 01/2022 - 07/2014
25	Ranibizumab (Lucentis)FDA Link 10/2022 - 03/2013
14	Fluorescein (Funduscein)FDA LinkGeneric 01/2022 - 01/2013
6	Pharmaceutical PreparationsIBA 01/2022 - 05/2017
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2019
5	brolucizumabIBA 01/2022 - 12/2018
4	N-acetyltryptophanamide (NATA)IBA 04/2022 - 12/2014
4	Endothelial Growth FactorsIBA 01/2022 - 05/2017
4	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 01/2021 - 01/2018
4	Fluocinolone Acetonide (Capex)FDA LinkGeneric 11/2020 - 01/2017
3	Adrenal Cortex Hormones (Corticosteroids)IBA 08/2019 - 05/2017
2	Verteporfin (Visudyne)FDA Link 11/2022 - 01/2009
2	CytokinesIBA 10/2022 - 01/2021
2	salicylhydroxamic acid (SHAM)IBA 05/2021 - 01/2017
2	pegcetacoplanIBA 01/2021 - 01/2020
2	SuspensionsIBA 01/2021 - 01/2018
2	SteroidsIBA 01/2018 - 01/2009
2	Anti-Bacterial Agents (Antibiotics)IBA 07/2016 - 11/2011
2	Transcription Factors (Transcription Factor)IBA 10/2004 - 07/2004
2	Proteins (Proteins, Gene)FDA Link 06/2003 - 12/2002
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 11/2022
1	formycin diphosphate (FDP)IBA 07/2022
1	Capsules (Microcapsules)IBA 01/2022
1	Neurofibromin 2 (Merlin)IBA 01/2022
1	Pentosan Sulfuric Polyester (Pentosan Polysulfate)FDA Link 01/2022
1	Complement System Proteins (Complement)IBA 01/2022
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2021
1	Complement Inactivating AgentsIBA 01/2021
1	AngiopoietinsIBA 01/2021
1	Immunoglobulins (Immunoglobulin)IBA 01/2021
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2021
1	abicipar pegolIBA 01/2020
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2020
1	Complement C3 (C3 Complement)IBA 01/2020
1	Mydriatics (Cycloplegics)IBA 10/2019
1	Angiopoietin-2IBA 01/2019
1	faricimabIBA 01/2019
1	frovatriptan (Allegro)FDA Link 02/2018
1	SiliconIBA 11/2017
1	Hemoglobins (Hemoglobin)IBA 09/2017
1	Vancomycin FDA LinkGeneric 01/2017
1	CoagulaseIBA 07/2016
1	Prednisone (Sone)FDA LinkGeneric 01/2016

Therapy/Procedure

22	Therapeutics 09/2022 - 05/2013
13	Injections 01/2022 - 07/2014
11	Lasers (Laser) 01/2021 - 02/2013
10	Vitrectomy 10/2022 - 01/2010
8	Intravitreal Injections 01/2022 - 04/2011
6	Light Coagulation 03/2020 - 01/2017
3	Retreatment 09/2021 - 01/2018
2	Scleral Buckling 07/2022 - 01/2022
2	Vitreoretinal Surgery 01/2022 - 10/2020
2	Operative Surgical Procedures 01/2021 - 06/2017
1	Cryotherapy (Therapy, Cold) 01/2021
1	Visual Prosthesis 12/2017
1	Glycemic Control 09/2017
1	Drug Therapy (Chemotherapy) 05/2017
1	Refractive Surgical Procedures 01/2017
1	Intraocular Injections 01/2017
1	Antibiotic Prophylaxis 07/2016
1	Solid-State Lasers 01/2016